Hairlessness
Hairlessness (Discovered in the Chinese Crested Dog) Linkage test

The Hairlessness (Discovered in the Chinese Crested Dog) variant causes dogs to have little or no hair, and is located in the FOXI3 gene.
More Info
Did you know?
Chinese Crested dogs without the Hairless variant are called "Powderpuff" type, and typically have long, silky hair!
How it works
One copy of this Hairlessness variant will result in the dog having a hairless body, with some hair remaining on the ears and some parts of the head. The remaining hair on the head can be long or short.
Health implications
Dogs with this variant commonly have missing or misshapen teeth and occasionally abnormalities of the ear. The medical term for this condition is ectodermal dysplasia. If two copies of the Hairlessness variant are inherited, it will cause early fetal death and resorption, so all dogs with this variant carry only one copy. Two Hairlessness variant dogs mated together will have smaller litter sizes and some normally haired dogs may be produced.
Prevalence
1 in 1,700 dogs
has one or more copy of this genetic variant in our testing.
Technical Details
Gene | FOXI3 |
---|---|
Variant | Duplication |
Chromosome | 17 |
Coordinate | 37,651,314 |
All coordinates reference CanFam3.1
References & Credit
Credit to our scientific colleagues:
Drögemüller, C., Karlsson, E. K., Hytönen, M. K., Perloski, M., Dolf, G., Sainio, K., … Leeb, T. (2008). A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science, 321(5895), 1462. View the article