Leg Length
Short Legs (Chondrodysplasia, CDPA)
Alternative Names: Breed-defining chondrodysplasia, CDPA, Chromosome 18 FGF4, FGF4L1

The Short Legs (CDPA) variant is associated with short legs due to chondrodysplasia. The variant is an insertion of an FGF4 gene on chromosome 18.
Breeds
Short Legs (Chondrodysplasia, CDPA) is common in:

Bichon Frise

Chihuahua

Pekingese

Basset Hound

Maltese

Havanese

Cardigan Welsh Corgi

Pembroke Welsh Corgi

Shih Tzu

Dachshund (Miniature Longhaired)

Lhasa Apso

Scottish Terrier

Dachshund (Miniature Shorthaired)

West Highland White Terrier
More Info
Did you know?
Many dogs are so small that the effects of this FGF4 variant will not be evident. Some surprising purebreds that commonly carry this gene, but don't obviously show the trait include the Chihuahua, Yorkshire Terrier, and Japanese Chin. Short legs are a competitive advantage for terriers, who are better able to fit into holes and burrows after prey without a significant loss in power. They are also a preferred characteristic for some breeds used for hunting on foot, such as the Basset Hound, as the hunter is better able to keep up with a dog with shorter legs.
How it works
Dogs with one copy of the Short Legs (CDPA) variant typically have some shortening of their legs, whereas with two copies there is more obvious shortening.
Health implications
Chondrodysplasia can cause limitation in mobility for some dogs.
Prevalence
3 in 10 dogs
have one or more copy of this genetic variant in our testing.
Technical Details
Gene | FGF4 |
---|---|
Variant | Insertion |
Chromosome | 18 |
Coordinate | 20,443,725 |
All coordinates reference CanFam3.1
References & Credit
Credit to our scientific colleagues:
Parker, H. G., VonHoldt, B. M., Quignon, P., Margulies, E. H., Shao, S., Mosher, D. S., … Ostrander, E. A. (2009). An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs. Science, 325(5943), 995–998. View the article