The clinical signs of hypocatalasia in dogs have not been described properly in the literature but include progressive gangrene in the oral cavity. In the human condition, the severity of signs can vary remarkably. The erythrocytes of affected dogs show no signs of catalase activity.

Treatment is pain management, supportive care, and symptomatic depending on the severity of the dog's clinical signs.

There are many responsibilities to consider when breeding dogs. Regardless of test results it is important that your dog is in good general health and that you are in a position to care for the puppies if new responsible owners are not found. For first time or novice breeders, advice can be found at most kennel club websites.

Although this disease is poorly discribed, our understanding is that this disease is autosomal recessively inherited, meaning that two copies of the mutation are needed for disease signs to occur. Avoiding use of carrier dogs for breeding purposes will ensure dogs in the resulting litter are clear of this mutation Breeding a carrier dog with one copy of the Hypocatalasia mutation with a clear dog with no copies of the Hypocatalasia mutation, will result in a litter containing half carriers and half clear dogs. Puppies in a litter which is expected to contain carriers should be tested prior to breeding. Carrier to carrier matings are not advised as the resulting litter may contain affected puppies. Please note: It is possible that disease signs similar to the ones caused by the Hypocatalasia mutation could develop due to a different genetic or clinical cause.